CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability.
نویسندگان
چکیده
CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.
منابع مشابه
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عنوان ژورنال:
- Cancer research
دوره 68 5 شماره
صفحات -
تاریخ انتشار 2008